EZYPRO® clinical applications

Advance Arrhythmia Diagnosis

Innovative tool for Cardiologists to enhance diagnosis rate of arrhythmia by increasing ECG monitoring from 24 hours to 14 days

Stroke
Prevention

Stroke Prevention

From prevention of first stroke to post stroke diagnosis to enable timely treatment of Afib to prevent subsequent strokes

Post Heart Surgery Monitoring

Up to 14-day monitoring post heart surgery / catheter ablation to allow surgeons and patients effective monitoring of surgical outcomes

Health
Check-up

Health Check-up

Early diagnosis of paroxysmal and silent arrhythmia through adult health check-ups to prevent development into severe cardiovascular diseases

Advance Arrhythmia Diagnosis

EZYPRO® long-term continuous ECG monitoring can accurately detect arrhythmia symptoms such as asymptomatic and paroxysmal atrial fibrillation

EZYPRO® - No miss in full record

60 %

of atrial fibrillation is paroxysmal, which can only be detected by long-term monitoring(2)

More than 30 %

of atrial fibrillation is asymptomatic(1)

Arrhythmia

Arrhythmia refers to all kinds of symptoms that are caused by abnormalities in the cardiac electrical conduction system. It includes irregular heartbeat, rapid heartbeat, as well as slow heartbeat. Severe arrhythmia will cause dizziness, syncope, and even cardiac arrest and sudden death. Research shows that half of the deaths from cardiovascular diseases are caused by sudden cardiac arrest from arrhythmia. While arrhythmia is often overlooked, the related diseases produce a massive economic burden. In most cases, arrhythmia can be controlled or treated through accurate diagnosis, pharmacotherapy, defibrillator implant, catheter ablation, and other surgeries.

Atrial Fibrillation

Atrial fibrillation is the most common type of arrhythmia. Compared to non-patients, atrial fibrillation patients have a much higher rate of death, heart failure, and stroke. Atrial fibrillation has a prevalence rate of 0.5% – 2%. There are approximately 100 million atrial fibrillation patients around the world, with about 10 million patients in China, 5.1 million patients in the U.S., and 4.5 million patients in Europe. However, due to an insufficient diagnosis rate, this is still only the tip of the iceberg. Since the occurrence of atrial fibrillation increases with age, population aging is expected to drastically increase the global number of atrial fibrillation patients by at least 2.5 times by year 2050. Most atrial fibrillations are paroxysmal and even asymptomatic, which result in the currently serious insufficient diagnosis rate.
Sources:
(1) : J Interv Card Electrophysiol. 2000 Jun;4(2):369-82.;
(2) : Stroke research and treatment. 2013 Mar: 849265 (5 pages)

Stroke Prevention

EZYPRO® long-term continuous ECG monitoring is able to detect atrial fibrillation in advance. It assists doctors to diagnose and devise treatment options

EZYPRO® - Detect Afib in advance

1500 million

Every year, about 15 million people around the world experience a stroke and 10% of them will suffer a recurrent stroke within one year(3)

30 %

of ischemic stroke is caused by atrial fibrillation(4)

More than 50 %

of the patients with an atrial fibrillation-induced stroke experience a prognosis of disability, severe disability, and death(5)

Atrial Fibrillation-Induced Ischemic Stroke

Atrial fibrillation patients are prone to thrombosis because the blood cannot be effectively moved out by atrial contraction, and a thrombus may flow out with the blood. A thrombus may cause a cerebral stroke if it enters cerebral blood vessels. The probability of stroke in atrial fibrillation patients is 5 times higher than average people, and the prognosis is often poor with a high recurrence rate. Atrial fibrillation-induced stroke can be prevented in advance through appropriate medications or surgeries.
Sources:
(3) : Neurol Clin. 2008 Jul (26): 871-895;
(4) : N Engl J Med 2014; 370:2478-2486;
(5):J Formos Med Assoc. 2016 Nov;115(11):893-952;

Post Heart Surgery Monitoring

EZYPRO® long-term continuous ECG monitoring assists doctors in examining post-operative conditions after any cardiac surgery

EZYPRO® - Assists Examining cardiac operative conditions

30 % - 40 %

of post-cardiac surgery patients will experience arrhythmia* (6)

10 %

Arrhythmia will recur in 10% of post-cardiac surgery patients during the recovery period(6)

30 % - 40 %

The 5-year recurrence rate for catheter ablation is 30% – 40%(7)

Cardiac Surgery

After cardiac surgery, surgical damage may cause arrhythmia during the recovery period. The most common observations include atrial premature contraction and atrial fibrillation. Most patients will recover within one week after surgery, but a few patients will experience recurrence after being discharged and this increases the risk of stroke. Through long-term heart rhythm follow-up and diagnosis, the status of post-operative recovery can be evaluated, and proper treatments can be given.

Catheter Ablation

Catheter ablation is one of the methods for treating arrhythmia. After confirming the mechanism of arrhythmia by a cardiac electrophysiological study, electric current can be applied to the lesion through electrode catheters for ablation. The success rate of catheter ablation in Taiwan is as high as 97%, which is unparalleled in the world. However, clinical research around the world has shown a 5-year recurrence rate of as high as 30-40% despite a successful catheter ablation. Regular follow-ups still need to be done. In the event of a recurrence, the doctor will need to devise treatment options and proceed with control by medication or another catheter ablation.

*: The incidence rate of arrhythmia after cardiac surgery: 37%-50% in valvular surgery; 11%-24% in cardiac transplantation; 15%-40% in CABG (coronary artery bypass graft)
Sources:
(6) : N Engl J Med 2014; 370:2478-2486;
(7) : J Cardiovasc Med (Hagerstown). 2011 Jun;12(6):390-5;
(8):Circ Arrhythm Electrophysiol. 2014 Apr;7(2):267-73

Health Check-up

EZYPRO® long-term continuous ECG monitoring allows arrhythmia to be detected early and treated early

EZYPRO® - Detected early and treated early

Examinations related to heart rhythm are relatively more deprived in adult health checkups. Yet, the complications from arrhythmia are often more serious and dangerous. Possible symptoms for arrhythmia include: fatigue, palpitation, chest tightness, dizziness, and syncope.

According to the American Heart Association, possible complications from arrhythmia include:

  1. Stroke
  2. Heart failure
  3. Cardiac arrest and even death

Currently, the most important method in diagnosing arrhythmia is ECG. By using the ECG to determine the type of arrhythmia and apply appropriate treatments, it is possible to prevent the occurrence of subsequent high-risk diseases.

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